Molecular Endocrinology Recent Publications

Ing, N. H., S. P. Brinsko, K. O. Curley, D. W. Forrest, C. C. Love, K. Hinrichs, M. M Vogelsang, D. D. Varner, T. H. Welsh, Jr. (2015) Dexamethasone acutely regulates  endocrine parameters in stallions and subsequently affects gene expression in testicular germ cells. Anim. Reprod. Sci. 152:47-54.

Johnson, L., T. H. Welsh Jr., K. O. Curley Jr., N. H. Ing, C. E. Johnston. (2015) Anatomy and physiology of the male reproductive system and potential targets of toxicants.  In: M. Caplan (ed.) “Reference Model in Biomedical Sciences” Waltham MA, Elsevier.

Ing, N. H. (2015) Post-transcriptional regulation of steroid hormone receptors. In: Post-transcriptional Regulation of Endocrine Function (eds. K. M. J. Menon and A. Goldstrum). Springer, NY (in press).

Ing, N. H., D. W. Forrest, C. C. Love, D. D. Varner (2014) Dense spermatozoa in stallion ejaculates contain lower concentrations of mRNAs encoding the sperm specific calcium channel 1, ornithine decarboxylase antizyme 3, aromatase and estrogen receptor alpha than less dense sperm. Theriogenology  84: 347-353.

Ing, N.H., D. Abi-Ghanem, M.M.K. Abbas, A. Kaushik L. Berghman, J. B. Puschett (2014) Marinobufagenin regulates permeability and gene expression of human brain microvascular endothelial cells. Am. J. Phys. 306:R918-924.

Ing. N. H.,  D. W. Forrest, P. K. Riggs, S. Loux**, C. C. Love, S. P. Brinsko, D. D. Varner, T. H. Welsh, Jr. (2014) Dexamethasone acutely down-regulates genes involved in steroidogenesis in stallion testes. J. Steroid Biochem. Mol. Biol. 453: 451-459.

Faucette, A. N., V. A. Maher, M. A. Gutierrez, J. M. Jucker, D. C. Yates, T. H. Welsh, Jr., M. Amstalden, G. R. Newton, L. C. Nuti, D. W. Forrest, N. H. Ing (2014)Temporal changes in histomorphology and gene expression in goat testes during postnatal development. J. Anim. Sci. 92: 4440-4449.

Loux, S., K. R. Crawford, N. H. Ing, L. Gonsalez-Fernandez, B. Macias-Garcia, C. C. Love, D. D. Varner, I. C. Velez, Y.-H. Choi, K. Hinrichs (2013) CatSper and the relationship of hyperactivated motility to calcium and pH kinetics. Biol. Reprod.  89:123.

Wang, Y., V. Brahmakshatriya, B. Lupiani, S. M.Reddy, B. Soibam, A. L. Benham, P. Gunaratne, H.-C. Liu, M. Trakooljul, N. H. Ing, R. Okimoto, H. Zhou (2012) Integrated analysis of microRNA expression and mRNA transcriptome in lungs of avian influenza virus infected broilers. BMC Genomics 13:278-293. PMC 3496578

Mortensen, C. J., Y.-H. Choi, N. H. Ing, D. C. Kraemer, M. M. Vogelsang, K. Hinrichs (2010) Heat shock protein 70 gene expression in equine blastocysts after exposure of oocytes to high temperatures in vitro or in vivo after exercise of donor mares. Theriogenology 74: 374-383.

Ing, N. H. (2010) Estradiol up-regulates expression of the A + U-rich binding factor 1 gene in the sheep uterus. J. Steroid Biochem. Mol. Biol. 122: 172-179. http://www.sciencedirect.com/science/article/pii/S096007601000289X
http://www.ncbi.nlm.nih.gov/pubmed/20621185
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Chen, C.-H., D. Abi-Ghanem, L. Njongmeta, J. Bray, W. Mwangi, S. D. Waghela, J. L. McReynolds, N. H. Ing, L. R. Berghman (2010) Production and characterization of monoclonal antibodies against chicken CD40. J. Poultry Sci. 34: 1139-1143.

Massuto, D. A., E. C. Kneese, G. A. Johnson, R. C. Burghardt, R. N. Hooper, N. H. Ing, L. A. Jaeger (2010) Transforming growth factor beta (TGFbeta) signaling is activated during porcine implantation: proposed role for latency associated peptide-integrins at the conceptus-maternal interface. Reproduction 139: 1470-1626.

Massuto, D. A., E. C. Kneese, G. A. Johnson, R. C. Burghardt, R. N. Hooper, N. H. Ing, L. A. Jaeger (2010) Transforming growth factor beta (TGFbeta) signaling is activated during porcine implantation: proposed role for latency associated peptide-integrins at the conceptus-maternal interface. Reproduction 139: 1470-1626.

Massuto, D. A., R. N. Hooper, E.C. Kneese, G. A. Johnson, N. H. Ing, B. R. Weeks, L. A. Jaeger (2009) Intrauterine infusion of latency associated peptide (LAP) during early porcine pregnancy affects conceptus elongation and placental size. Biol. Reprod. 82: 534-542 (Impact Factor 4.0)

Laughlin, A., T. H. Welsh Jr., C. C. Love, D. D. Varner, A. R. Parrish, D. W. Forrest, N. H. Ing (2009) In vitro culture of precision-cut testicular tissue as a novel tool for the study of responses to LH. In Vitro Cell Dev. Biol. – Animal 46:45-53.

Mortensen, C. J., Y. H. Choi, K. Hinrichs, N. H. Ing, D. C. Kraemer, S. G. Vogelsang, M. M. Vogelsang (2009) Embryo recovery from exercised mares. Anim. Reprod. Sci. 110: 237-44

Ing, N. H., D.A. Massuto, L.A. Jaeger (2008) Estradiol regulates A+U-rich RNA-binding factor 1 p45 binding to stabilizing regions within the 3′ untranslated regions of estrogen receptor-a mRNA. J. Biol. Chem. 283:1764-72.

Ing, N.H., R.L. Wolfskill, S. Clark, J.A. deGrauuw, C.A. Gill (2006) Steroid hormones acutely regulate expression of a nudix protein-encoding gene in the endometrial epithelium of sheep. Mol. Reprod. Devel.73:67-76.

Jaeger, J.A., A.K. Speigel, N.H. Ing, G.A. Johnson, F.W. Bazer, R.C. Burghardt (2005) Functional effects of transforming growth factor b on adhesive properties of porcine trophectoderm. Endocrinology 146:3933-42.

Zhang, Y. and N. H. Ing (2004) Cell-specific expression of oestrogen-responsive genes in uteri of cyclic, early pregnant and ovariectomized ewes. Theriogenology 62:403-14.

Ing, N. H., A. Laughlin, D. D. Varner, T. H. Welsh Jr., D. W. Forrest, T. L. Blanchard and L. Johnson (2004) Gene expression in the spermatogenically inactive “dark” and the maturing “light” testis tissue of the prepubertal colt. J. Androl. 25:535-44. Abstract

Mitchell, D. C. and N. H. Ing (2003) Estradiol stabilizes estrogen receptor mRNA in sheep endometrium via discrete sequence elements in its 3′ untranslated region. Mol. Endocrinol. 17: 562-574. Abstract

Farnell, Y.Z. and N. H. Ing (2003) Endometrial effects of selective estrogen receptor modulators on estrogen-responsive gene expression. J. Steroid Biochem. Mol. Biol. 84: 513-526. Abstract

Farnell, Y.Z. and N. H. Ing (2003) Myometrial effects of selective estrogen receptor modulators on estrogen-responsive gene expression. J. Steroid Biochem. Mol. Biol. 84: 527-536. Abstract

Farnell, Y.Z. and N. H. Ing (2003) Estradiol and a selective estrogen receptor affect steroid hormone receptor messenger RNA levels and turnover in explant cultures of sheep endometrium. In Vitro Cell Dev. Biol. 38: 595-600. Abstract

Farnell, Y.Z. and N. H. Ing (2003) The effects of estradiol and selective estrogen receptor modulators on gene expression and messenger RNA stability in immortalized sheep endometrial stromal cells and human endometrial adenocarcinoma cells. J. Steroid Biochem. Mol. Biol. 84: 453-61. Abstract

Robertson JA, Zhang Y, Lindahl LS, Ing NH 2002 Estradiol up-regulates estrogen receptor messenger ribonucleic acid in endometrial carcinoma (Ishikawa) cells by stabilizing the message. J Mol Endocrinol 29:125-135 [Abstract]

Wilker, C. E., N. H. Ing, T. H. Welsh Jr. and L. Johnson (2001) Syngeneic testicular grafts produce testosterone and express Sertoli cell genes characteristic of intact testes. Advances in Reproduction V: 113-31.

Robertson JA, Zhang Y, Ing NH 2001 ICI182780 acts as a partial agonist and antagonist of estradiol effects in the sheep uterus. J Steroid Biochem Mol Biol 77: 281-287 [Abstract]

Miller, S., D. Kennedy, J. Thomson, F. Han, R. Smith, N. H. Ing, J. Piedrahita and D. Busbee (2000) A rapid and sensitive reporter gene system using green fluorescent protein expression to detect chemicals with estrogenic activity. Toxicol. Sci 55(1):69-77.

Scott CJ, Tilbrook AJ, Simmons DM, Rawson JA, Chu S, Fuller PJ, Ing NH, Clarke IJ (2000) The distribution of cells containing estrogen receptor-alpha (ERalpha) and ERbeta messenger ribonucleic acid in the preoptic area and hypothalamus of the sheep: comparison of males and females. Endocrinology 141: 2951-2962 [Abstract]

Scott CJ, Pereira AM, Rawson JA, Simmons DM, Rossmanith WG, Ing NH, Clarke IJ (2000) The distribution of progesterone receptor immunoreactivity and mRNA in the preoptic area and hypothalamus of the ewe: upregulation of progesterone receptor mRNA in the mediobasal hypothalamus by oestrogen. J Neuroendocrinol 2: 565-575 [Abstract]

Flynn, N.E., C. J. Meininger, K. Kelly, N. H. Ing, S. M. Morris and G. Wu (1999) Glucocorticoids mediate the enhanced expression of intestinal type II arginase and argininosuccinate lyase in postweaning pigs. J. Nutrition 129: 799-803.

Ing NH, Robertson JA (1999) Regulation of hormone receptor gene expression. In: Carson D (ed) Embryo Implantation: Molecular, cellular, and clinical aspects. Springer-Verlag, New York, pp 287-298

Ing NH, Ott TL (1999) Estradiol up-regulates estrogen receptor-alpha messenger ribonucleic acid in sheep endometrium by increasing its stability. Biol Reprod 60: 134-139 [Abstract]

Robertson JA, Bhattacharyya S, Ing NH (1998) Tamoxifen up-regulates oestrogen receptor-alpha, c-fos and glyceraldehyde 3-phosphate-dehydrogenase mRNAs in ovine endometrium. J Steroid Biochem Mol Biol 67: 285-292 [Abstract]

Hutchinson RW, Ing NH, Burghardt RC (1998) Induction of c-fos, and cytochrome c oxidase subunits I and II by gossypol acetic acid in rat liver cells. Cell Biol Toxicol 14: 391-399 [Abstract]

Zou K, Ing NH (1998) Oestradiol up-regulates oestrogen receptor and cyclophilin mRNA concentrations in endometrium, but has opposite effects in liver. Mol Biol 64: 231-237 [Abstract]

Ing NH, Tornesi BT (1997) E2 up-regulates estrogen receptor and progesterone receptor gene expression in specific uterine cells. Biol. Reprod. 56: 1205-1215 [Abstract]

Ing NH, Spencer TE, Bazer FW (1996) Estrogen enhances expression of the estrogen receptor gene in endometrium by a posttranscriptional mechanism. Biol Reprod 54: 591-599 [Abstract]

Adams, S. H., V. Esser, N. F. Brown, N. H. Ing, L. Johnson, D. W. Foster, and J. D. McGarry (1998) Expression and possible role of muscle-type carnitine palmitoyltransferase I during sperm development in the rat. Biol. Reprod. 59: 1399-1405.

Gupta, A., N. H. Ing, F. W. Bazer, L. S. Bustamante, and L. A. Jaeger (1998) Beta transforming growth factors (TGFs) at the porcine conceptus-maternal interface. Part I: Expression of TGF1, TGF2 and TGF3 messenger ribonucleic acids. Biol Reprod. 59:905-10.

Robertson, J. A., S. Bhattacharyya, and N. H. Ing (1998) Tamoxifen acts as an oestrogen agonist in endometrium of the ewe. J. Steroid Biochem. Mol. Biol. 67:285-92.

Zou, K., and N. H. Ing (1997). Oestradiol up-regulates oestrogen receptor and cyclophilin mRNA concentrations in endometrium, but down-regulates them in liver. J. Steroid Biochem. Mol. Biol. 64: 231-237.

Spencer, T. E., N. H. Ing, T. L. Ott, J. S. Mayes, W. C. Becker, G. H. Watson, M. A. Mirando and F. W. Bazer. (1995). Intrauterine injection of ovine interferon-t (IFN-t) alters oestrogen receptor and oxytocin receptor expression in the endometrium of cyclic ewes. J. Mol. Endocrinol. 15:203-220.

Ing, N. H., J.M. Beekman, D. J. Kessler, M. Murphy, K. Jayaraman, J. G. Zendegui, B. W. O’Malley, M. E. Hogan and M.-J. Tsai. (1993). In vivo transcription of a progesterone-responsive gene is specifically inhibited by a triplex-forming oligonucleotide. Nuc. Acids Res. 21:2789-2796. PMC 309654

Ing, N. H., J. M. Beekman, S. Y. Tsai, M.-J. Tsai, and B. W. O’Malley. (1992). Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II). J. Biol. Chem. 267:17617-17623.

Wang, L.-H., N. H. Ing, S. Y. Tsai, B. W. O’Malley, and M.-J. Tsai. (1991). The COUP-TF compose a family of functionally related transcription factors. Gene Expression. 1:207-216.

Allan, G. F., N. H. Ing, S. Y. Tsai, G. Srinivasan, N. L. Weigel, E. B. Thompson, M.-J. Tsai, and B. W. O’Malley. (1991). Synergism between steroid response and promoter elements during cell-free transcription. J. Biol. Chem. 266:5905-5910.

Kazemi, M., J. F. Amann, D. H. Keisler, N. H. Ing, R. M. Roberts, G. Morgan, and F. B. P. Wooding. (1990). A progesterone-modulated, low-molecular-weight protein from the uterus of the sheep is associated with crystalline inclusion bodies in uterine epithelium and embryonic trophectoderm. Biol. Reprod. 43:80-96.

Ing. N. H., H. Francis, J. J. McDonnell, J. F. Amann, & R. M. Roberts (1989). Progesterone induction of the uterine milk proteins: major secretory proteins of sheep endometrium. Biol. Reprod. 41:643-654.

Ing, N. H., & R. M. Roberts (1989). The major progesterone-modulated proteins of the sheep uterus are serpins. J. Biol. Chem. 264:3372-3379.

Hansen, P. J., N. H. Ing, R. J. Moffatt, G. A. Baumbach, P. T. K. Saunders, F. W. Bazer, & R. M. Roberts (1987). Biochemical characterization and biosynthesis of the uterine milk proteins of the pregnant sheep uterus. Biol. Reprod. 36:405-418.

Texas A&M University | College of Veterinary Medicine | Department of Animal Science | Program in Genetics | Reproductive Biology

Questions or comments? Please contact Dr. Nancy Ing.

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